Micky van de Ven Double Halts Everton's Run at New Home Ground
The Dutch defender emerged as the first defender to net two goals in a Premier League game for Tottenham since Jan Vertonghen in March 2013.
Match summary
The Spurs defender nods home twice in opening period
The home side's Jake O'Brien has equalizer disallowed after VAR review
Senegalese midfielder nets third in dying moments
This loss is the Merseyside club's first at Hill Dickinson Stadium
Micky van de Ven scored twice as Tottenham extended their unbeaten run in away games in the top division and handed Everton their initial loss at their new home.
Everton were unbeaten in their last five matches at their new ground at the dockside location, having left their historic home behind after more than a century at the conclusion of the previous campaign.
But Spurs captain Van de Ven pounced twice from set-pieces in the first half to put their impressive record at jeopardy, and they were unable to turn it around before the midfielder - assisted by former Toffees attacker Richarlison - nodded in a final goal to put the game to bed.
The Everton defender thought he had equalized the tally a short while after the defender's first goal, directing a bullet header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, missed a number of chances, while the Italian goalkeeper made a succession of excellent stops to guarantee Tottenham went five matches on the road without defeat in the English top flight.
But the VAR stepped in, instructing Craig Pawson to check the goal on the screen and the referee decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Spurs keeper.
The win elevates the manager's side into third place in the division, five points off north London rivals and leaders the Gunners.
The Merseyside club remain 14th and sit six points ahead of the drop zone.
Tottenham analysis: The defender excels in duties at both ends of the field
Following a drab weekday display in the Champions League against Monaco, where they managed a only attempts on goal, the manager chose the French striker up front instead of ex-Everton forward the Brazilian.
The summer signing was failed to make much of an impact before being replaced for the substitute after 60 minutes on the field, but it turns out he proved unnecessary in the final outcome.
Centre-back Van de Ven transformed into an offensive threat to be reckoned with.
Spurs' first goal came from a well-worked set-piece play, with the midfielder directing the ball toward the six-yard box for an free the defender to head home.
And Ven de Ven - stepping up as captain in Cristian Romero's unavailability - added his second in first-half stoppage time as he outjumped Jordan Pickford to head home.
The Dutchman was equally outstanding in defence, partnering effectively with his defensive colleague as the pair handled excellently with the 34 crosses thrown their way by the opposition.
Toffees breakdown: Toffees lacking finishing touch
The club's new home had been a fortress, but it appears the freshness may have worn off somewhat and supporters flocked to the gates after the midfielder's final goal for Tottenham.
The end in the team's winning streak at home won't be a massive concern for David Moyes, but their attacking woes will be.
Beto and Thierno Barry - the Toffees' pair of established centre-forwards - had scored only one league goal between them before Sunday's match.
And they were unable to add to that miserable tally on a damp and dreary night on Merseyside.
Beto's form was epitomized when he opted to overhead kick a clear chance from near the goal, despite having space and time to readjust for a more conventional attempt that would have challenged the keeper.
Barry, too, was unable to make an impact after coming on for Beto in the 65th minute.
It wasn't for a shortage of opportunity. The majority of Everton's offensive moves came through Grealish and Ndiaye, who relentlessly whipped dangerous crosses into the Tottenham box.
What next for these two sides?
The Toffees: The team travel to Sunderland in the top flight on Monday, 3 November at 20:00 GMT.
Spurs: The London club go to St James' Park on Wednesday, 29 October for their next round League Cup match against the Magpies.